SZL P1-41( SZL-P1-41 | SZL P1 41 | SZLP141 | SKP2 E3 Ligase Inhibitor III )

Catalog No. M13562 CAS No. 222716-34-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SZL P1-41
Note

Research use only, not for human use.
Brief Description

A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
Description

A small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro; specific diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex; inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells; exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
In Vitro

SZL P1-41 (5-20μM; 24 hours) induces endogenous p27 protein expression in PC3 cells and also induced expression of p21, another Skp2 substrate.
In Vivo

SZL P1-41 (40-80 mg/kg; i.p.) displays a potent effect on inhibiting prostate and lung tumor growth in Nude mice bearing A549 and PC3 tumor xenografts.
Synonyms

SZL-P1-41 | SZL P1 41 | SZLP141 | SKP2 E3 Ligase Inhibitor III
Pathway

Proteasome/Ubiquitin
Target

E3 Ubiquitin Ligase
Recptor

Skp2
Research Area

Cancer
Indication

——

CAS Number

222716-34-9
Formula Weight

420.524
Molecular Formula

C24H24N2O3S
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1C(C2=NC3=CC=CC=C3S2)=COC4=C(CN5CCCCC5)C(O)=C(CC)C=C14
Chemical Name

4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-

1. Chan CH, et al. Cell. 2013 Aug 1;154(3):556-68.

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